Endocrine and Metabolic Emergencies
Recognise thyroid, adrenal, pituitary, calcium and sodium emergencies and correct abnormalities safely.
How to prepare for PLAB 1
Practise recognising the immediate clinical task, ruling in or out dangerous alternatives, choosing the safest next step and closing the loop.
Core concepts
Concept 1
Endocrine emergencies often combine non-specific deterioration with a distinctive biochemical pattern.
Exam cue: Stabilise first, obtain critical samples when safe and treat without inappropriate delay.
Concept 2
Rapid correction of chronic electrolyte disturbance can itself cause severe harm.
Exam cue: Estimate chronicity and neurological severity before correction.
Risk pitfalls and guardrails
Correcting sodium too quickly.
Guardrail: Avoid an option that names a plausible diagnosis but ignores physiology, contraindications, competence, patient priorities or follow-up.
Delaying steroids in suspected adrenal crisis.
Guardrail: Avoid an option that names a plausible diagnosis but ignores physiology, contraindications, competence, patient priorities or follow-up.
Memory anchors
What is the immediate response to adrenal crisis?
Resuscitation, prompt parenteral glucocorticoid, fluids and treatment of the precipitant.
What governs sodium correction?
Symptoms, severity, likely duration, volume status and strict correction limits with monitoring.
What makes severe hypercalcaemia urgent?
Neurological, cardiac, renal or marked biochemical effects requiring fluids and cause-directed care.
How is thyroid emergency recognised?
Severe systemic decompensation with supportive thyroid history and biochemical evidence.
Why take critical samples early?
Some endocrine treatments alter diagnostic hormone results, but sampling must not delay life-saving care.
Checkpoint rule
Do the check-up only after you can summarize each concept in one sentence and identify one dangerous pitfall from memory.
Knowledge Check (after reading)
Short check-up to confirm understanding of this module.
Check-up Questions
A patient on long-term steroids has vomiting, hypotension, hyponatraemia and hypoglycaemia after abrupt cessation. What is the priority?
A patient has weight loss, hyperpigmentation, postural hypotension, low sodium and high potassium. What is likely?
Answer all questions to submit.
Next step personalized recommendations
Continue learning
Move forward only after this module is stable.
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