UK PLAB 1 applied knowledge study guide
Current GMC PLAB 1 structure, results guidance, MLA transition, original and updated MLA content maps, and Good medical practice reviewed 29 July 2026
601 practice questions
150 flashcards
Completely free

PLAB 1 Study Guide

Prepare for 180 five-option applied knowledge questions by connecting common and acute clinical presentations with safe F2-level decisions, UK evidence and professional duties.

180 questions
180 minutes
5-option SBA

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Jump into a mixed set drawn from 601 free practice questions.

Free Practice Questions

Exam structure

Know the split before you start drilling

PLAB 1 Applied Knowledge Test

100 items

180 scored + 0 pretest

Assessment

Applied knowledge test

GMC tests application of knowledge, not isolated factual recall.

Questions

180

Each short scenario is followed by one question and five answer options.

Time allowed

3 hours

This averages one minute per item, including answer-sheet completion.

Delivery

Written exam

Candidates mark a paper answer sheet with HB pencil at an examination venue.

Calculator

Not allowed

GMC prohibits calculators and electronic devices in the examination room.

Clinical level

F2 entry

The standard reflects a doctor entering Foundation Programme Year 2.

Blueprint

MLA content map

Original map through August 2026; updated map from September 2026.

Pass mark

Sitting-specific

GMC uses Angoff standard setting plus one standard error of measurement.

Start here

How to prepare for PLAB 1

Fix the official boundary and sitting-specific content map before building clinical depth.

1

1. Identify your map version

Use the original MLA content map for a sitting through August 2026 and the updated map for a sitting from September 2026.

2

2. Learn the ten feedback areas

Use the GMC result categories to balance clinical-system coverage without treating them as fixed exam weights.

3

3. Think across all six MLA domains

For each presentation, integrate clinical context, knowledge, capabilities, practical steps, differential diagnosis and conditions.

4

4. Prioritise unsafe delay

Practise recognising deterioration, stabilising the patient and escalating before refining a non-urgent diagnosis.

5

5. Rehearse one-minute decisions

Read the exact task, commit to one best option and transfer it carefully to the answer sheet.

About the exam

PLAB 1 Exam structure

An independent study guide aligned to the current GMC PLAB 1 guide, the applicable MLA content map and UK Foundation Programme Year 2 entry standard.

Issuer and path

PLAB 1 Study Guide is administered through General Medical Council. Check official resources before booking, retesting, or relying on a stale requirement.

PLAB 1 Applied Knowledge Test

100 items

180 scored + 0 pretest

A three-hour written examination of 180 single-best-answer questions, each with five options.

Before your sitting

Recheck the GMC guide and direct booking communications for your content-map version, venue, identification, allowed items, adjustments, timetable and any policy change.

Official Outline Coverage Map

Coverage is mapped to official outline item counts so content depth can be checked without hard-coding a single exam.

Official outline
TopicOfficial outline itemsYour questionsYour flashcardsConfidence
Antenatal Care and Maternal Emergencies0205
Strong
Labour and Postpartum Care0205
Strong
Gynaecology, Sexual and Reproductive Health0205
Strong
Acute Kidney Injury, Fluids and Electrolytes0205
Strong
Chronic Kidney and Renal Disease0205
Good
Urinary and Urological Presentations0205
Strong
Neurological Emergencies0225
Strong
Neurology, Cognition and Chronic Symptoms0215
Good
Skin, Eye and ENT0215
Strong
Trauma and Fractures0205
Strong
Rheumatology, Bone and Joint Infection0195
Good
Back Pain, Soft Tissue and Rehabilitation0195
Good
Depression, Self-harm and Suicide Risk0205
Strong
Psychosis, Cognition and Capacity0195
Strong
Anxiety, Substance Use and Eating Disorders0195
Good
Acute Abdomen and Gastrointestinal Bleeding0215
Strong
Liver, Biliary and Pancreatic Disease0215
Good
Chronic Gastrointestinal Disease and Nutrition0205
Good
Diabetes and Diabetic Emergencies0225
Strong
Endocrine and Metabolic Emergencies0215
Strong
Haematology, Coagulation and Transfusion0215
Strong
The Acutely Unwell Child0205
Strong
Neonatal, Growth and Developmental Care0205
Good
Common Paediatrics, Safeguarding and Transition0205
Strong
Chest Pain and Cardiac Disease0235
Strong
Breathlessness and Respiratory Disease0225
Strong
Shock, Thromboembolism and Perioperative Care0225
Strong
Acute Care, Infection and Prescribing0165
Strong
Professional Law, Communication and Safeguarding0165
Strong
Evidence, Quality, Population Health and Uncertainty0165
Strong

How to use this guide

How to prepare for PLAB 1

Practise recognising the immediate clinical task, ruling in or out dangerous alternatives, choosing the safest next step and closing the loop.

1. Read the exact task

Identify whether the question asks for diagnosis, investigation, immediate action, treatment, medicine change, referral or professional response.

2. Find the immediate threat

Use physiology, red flags and trajectory to decide whether stabilisation or escalation must come before diagnostic refinement.

3. Build a discriminating differential

Use age, context, onset and key positives or negatives to separate the dangerous, common and most likely explanations.

4. Apply UK evidence and duties

Choose current best practice, work within F2 competence, respect patient preferences and apply the relevant professional or legal requirement.

5. Select and close the loop

Pick the option that fully answers the stem and includes necessary reassessment, communication, monitoring, safety-netting or follow-up.

Ten feedback areas

Balance clinical-system coverage

Use the GMC result categories for navigation while applying every scenario across the six MLA map domains.

Reproductive Health

Obstetrics, gynaecology, sexual health and reproductive decisions across acute and continuing care.

60 items

Choose a topic to open below

Renal and Urology

Acute kidney injury, chronic renal disease, fluid and electrolyte problems, urinary presentations and urological emergencies.

60 items

Choose a topic to open below

Neurosciences and Senses (including Skin)

Neurological, dermatological, ophthalmic and ear, nose and throat presentations with time-critical red flags.

64 items

Choose a topic to open below

Musculoskeletal

Trauma, bone and joint emergencies, inflammatory disease, back pain, rehabilitation and safe analgesia.

58 items

Choose a topic to open below

Mental Health

Risk, capacity, common mental illness, severe mental illness, substance use and person-centred crisis care.

58 items

Choose a topic to open below

Gastrointestinal

Acute abdominal presentations, gastrointestinal bleeding, hepatobiliary and pancreatic disease, chronic disease and nutrition.

62 items

Choose a topic to open below

Endocrine, Metabolic and Clinical Haematology

Diabetes, endocrine emergencies, metabolic disturbance, anaemia, coagulation, transfusion and haematological disease.

64 items

Choose a topic to open below

Child and Adolescent Health

The acutely unwell child, neonatal and developmental care, common paediatric illness, safeguarding and transition.

60 items

Choose a topic to open below

Cardiorespiratory

Cardiac and respiratory emergencies, chronic disease, thromboembolism, shock and perioperative risk.

67 items

Choose a topic to open below

Ethics and Other

Cross-system acute care, prescribing, infection, law, ethics, communication, safeguarding, evidence and patient safety.

48 items

Choose a topic to open below

Reproductive Health
PLAB 1 AKT

Antenatal Care and Maternal Emergencies

Recognise pregnancy complications, prioritise maternal stabilisation and choose safe investigation, treatment and escalation.

Key rules

Rule 1

Pregnancy changes differential diagnosis, investigation choices, medicine risk and thresholds for senior obstetric input.

Exam cue: Confirm gestation and stability before selecting the next step.

Rule 2

Maternal resuscitation and time-critical escalation take priority when the mother or fetus is at risk.

Exam cue: Use the safest effective test or treatment without delaying emergency care.

Common traps

Withholding necessary care solely because the patient is pregnant.

Prevention: Avoid an option that names a plausible diagnosis but ignores physiology, contraindications, competence, patient priorities or follow-up.

Focusing on fetal assessment before stabilising the mother.

Prevention: Avoid an option that names a plausible diagnosis but ignores physiology, contraindications, competence, patient priorities or follow-up.

Memory anchors

What frames an obstetric emergency?

Maternal ABCDE, gestation, bleeding or pain, fetal concern and urgent obstetric escalation.

What comes first in maternal collapse?

Standard resuscitation with pregnancy adaptations and immediate expert help.

How should medicines in pregnancy be judged?

Balance maternal benefit, fetal risk, gestation, dose and safer effective alternatives.

What makes hypertension in pregnancy urgent?

Severe pressure, neurological symptoms, organ dysfunction or fetal compromise.

What closes antenatal management?

Clear escalation, safety-netting, follow-up and communication with maternity services.

Next best moves

Quick check-up

Use a short quiz to confirm the rule pattern is actually sticking.

Check-up Questions

1-2 question checkpoint

A 29-year-old at 8 weeks' gestation has severe unilateral pelvic pain, shoulder-tip pain, pulse 118 and blood pressure 82/48 mmHg. What is the best next step?

A primigravida at 34 weeks has blood pressure 168/112 mmHg, headache, visual scotomata and epigastric pain. What should happen now?

Answer all questions to submit.

Next step personalized recommendations

Open another topic next

Official resources

Verify the details with the official sources

Use these links for eligibility, scheduling, handbook rules, and issuer updates. Our guide helps you study; official sources tell you what the testing partner currently requires.

FAQ

Common PLAB 1 questions

Is this an official GMC resource?

No. This is an independent study guide. The current GMC PLAB guide, MLA content map, Good medical practice and direct candidate communications remain authoritative.

What is the current PLAB 1 format?

PLAB 1 is a three-hour written applied knowledge test with 180 multiple-choice questions. Each item starts with a short scenario and asks for one answer from five options.

What clinical level does PLAB 1 test?

It tests common, important or acute conditions encountered by doctors appointed to Foundation Programme Year 2, together with long-term condition management in primary care. Advanced GP duties are excluded.

Has the MLA replaced PLAB 1?

The test is still called PLAB 1, but GMC states that it is compliant with MLA requirements and its questions are based on the MLA content map.

Which MLA content map applies to my sitting?

For PLAB assessments up to and including August 2026, GMC says the original MLA content map remains the reference. The updated content map applies to PLAB assessments from September 2026. Check the date of the sitting, not the date you began studying.

What changed in the updated MLA content map?

The six-domain structure remains, but the old appendix linking presentations and conditions to selected clinical areas was removed. The conditions list is explicitly non-exhaustive, and expectations around uncertainty, holistic care, health inequalities, communication, prescribing, escalation and professional behaviour are clearer.

Are the ten feedback areas the six MLA domains?

No. GMC reports PLAB 1 performance under ten clinical feedback areas. The MLA map also has six cross-cutting domains: clinical practice, professional knowledge, capabilities, practical skills and procedures, patient presentations, and conditions. A realistic question can draw from several map domains at once.

Does GMC publish fixed topic weights?

No. GMC publishes the 180-question total and ten feedback areas but not fixed item allocations across those areas. The 601 practice questions in this module use an internal balanced-coverage allocation, not official exam weights.

How is the PLAB 1 pass mark set?

Each correct answer earns one mark. GMC sets the pass mark for each sitting using the Angoff method and adds one standard error of measurement. There is no fixed pass percentage or expected pass rate.

Can I use a calculator?

No. GMC states that calculators and electronic devices are not allowed in the examination room, so dose and fluid calculations should be rehearsed accurately without one.

How many attempts are allowed?

After four failed attempts at either PLAB part, a candidate must complete at least 12 months of qualifying additional learning and development and apply for an exceptional fifth and final attempt.

Which professional standards should I use?

Use current Good medical practice and its explanatory guidance, together with applicable UK law, local systems and current authoritative clinical guidance. Where law differs among UK nations, apply the jurisdiction in the scenario.

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